ABSTRACT
La tetralogía de Fallot (TOF) se ha asociado con varios defectos genéticos y puede presentarse simultáneamente con ma-nifestaciones craneofaciales. El paciente odontológico con TOF puede requerir algunos cambios en el plan de tratamiento. El objetivo del presente reporte de caso es mostrar que las extracciones dentales se pueden llevar a cabo en personas con TOF bajo anestesia local, una vez que se realiza la correcta planificación. Cinco dientes supernumerarios fueron extraídos de un paciente adolescente con TOF y se realizó profilaxis antibiótica para evitar la endocarditis infecciosa. La paciente regresó para una nueva evaluación al 7mo día postoperatorio. Él informó que no había sentido molestias o dificultades para comer. El examen bucal postoperatorio confirmó la reparación eficiente de los tejidos en todas las regiones expuestas al procedimiento quirúrgico, sin ninguna señal de infección.
Tetralogy of Fallot (TOF) has been associated with several genetic defects and may present concurrently with craniofacial manifestations. The dental patient with TOF may require some changes in the treatment plan. The aim of the present case report is to show that dental extractions can be carried out in TOF individuals under local anaesthesia, since the correct planning is done. Five supernumerary teeth were extracted in adolescent with TOF and antibiotic prophylaxis was performed to avoid infective endocarditis. The patient returned for re-evaluation on the 7th postoperative day. He reported that there had been no discomfort or difficulty in eating. An oral examination confirmed that all extraction sites were healing well, without any indication of infection.
A Tetralogia de Fallot (TOF) está associada a diversas alterações genéticas e pode concomitantemente apresentar manifes-tações craniofaciais. O paciente com comprometimento odontológico geralmente necessita de alterações em seu plano de tratamento. O objetivo do presente estudo, é mostrar, por meio de um relato de caso, que procedimentos cirúrgicos odon-tológicos podem ser realizados em pacientes em TOF sob anestesia local, desde que o correto planejamento seja realizado. Cinco dentes supranumerários foram extraídos de um paciente adolescente com TOF e a profilaxia antibiótica foi realizada previamente ao procedimento cirúrgico, devido ao risco de endocardite infecciosa. O paciente retornou para reavaliação após 7 dias da realização do procedimento relatando que não houve desconforto ou dificuldade para se alimentar. O exame bucal pós-operatório, mostrou reparação tecidual eficiente em todas as regiões expostas ao procedimento cirúrgico, sem qualquer sinal de infecção.
Subject(s)
Surgical Procedures, Operative , Surgery, Oral , Tetralogy of Fallot , Tooth Extraction , Craniofacial Abnormalities , Heart Diseases , Oral Hygiene , Case Reports , Antibiotic Prophylaxis , Endocarditis , Anesthesia, LocalABSTRACT
Objectives: To analyze the frequency of βS-globin haplotypes and alpha-thalassemia, and their influence on clinical manifestations and the hematological profile of children with sickle cell anemia. Method: The frequency of βS-globin haplotypes and alpha-thalassemia and any association with clinical and laboratorial manifestations were determined in 117 sickle cell anemia children aged 371 months. The confirmation of hemoglobin SS and determination of the haplotypes were achieved by polymerase chain reaction-restriction fragment length polymorphism, and alpha-thalassemia genotyping was by multiplex polymerase chain reaction (single-tube multiplex-polymerase chain reaction). Results: The genotype distribution of haplotypes was 43 (36.7%) Central African Republic/Benin, 41 (35.0%) Central African Republic/Central African Republic, 20 (17.0%) Rare/atypical, and 13 (11.1%) Benin/Benin. The frequency of the α3.7 deletion was 1.71% as homozygous (−α3.7/−α3.7) and 11.9% as heterozygous (−α3.7/αα). The only significant association in respect to haplotypes was related to the mean corpuscular volume. The presence of alpha-thalassemia was significantly associated to decreases in mean corpuscular volume, mean corpuscular hemoglobin and reticulocyte count and to an increase in the red blood cell count. There were no significant associations of βS-globin haplotypes and alpha-thalassemia with clinical manifestations. Conclusions: In the study population, the frequency of alpha-thalassemia was similar to published data in Brazil with the Central African Republic haplotype being the most common, followed by the Benin haplotype. βS-globin haplotypes and interaction between alpha-thalassemia and sickle cell anemia did not influence fetal hemoglobin concentrations or the number of clinical manifestations...
Subject(s)
Humans , Child , alpha-Thalassemia , Anemia, Sickle Cell , Beta-Globulins , Child , HaplotypesABSTRACT
Purpose: To quantify keloid fibroblasts after irradiation with 470nm blue LED, in vitro. Methods: Fibroblasts from keloid and adjacent skin have been obtained from 6 patients. Cells have been cultivated and maintained in DMEM culture medium. In Petri dishes, they were irradiated with energy doses of 6J, 12J and 18J. After 24 h, counting was done by the average of the triplicates for each sample. Results: There were no significant differences in the number of irradiated keloid fibroblasts at the studied doses (p=0.261). In adjacent skin fibroblasts, differences were observed (p=0.025) concerning the doses of 18 J and 6 J (p=0.03). Conclusions: There was a reduction in the number of adjacent skin fibroblasts irradiated with 470nm blue LED at the energy dose of 18 J compared to the ones irradiated at the energy dose of 6 J. There were no changes in keloid fibroblasts counting at any of the doses applied, 24 h after irradiation.
Objetivo: Quantificar fibroblastos de quelóide após irradiação com LED azul de 470nm, in vitro. Métodos: Foram obtidos fibroblastos de quelóide e pele adjacente, de seis pacientes. As células foram cultivadas e mantidas em meio de cultura DMEM. Em placas de Petri, receberam irradiação com doses de energia de 6J, 12J e 18J. Após 24 horas a contagem foi feita pela média da triplicata para cada amostra. Resultados: Não houve diferença na quantidade de fibroblastos de quelóide irradiados nas doses estudadas (p=0,261). Observou-se diferença nos fibroblastos de pele adjacente (p=0,025), com relação às doses de 18 J e 6 J (p=0,03). Conclusões: Houve redução dos fibroblastos de pele adjacente irradiados com LED azul de 470 nm na dose de energia de 18 J em relação à dose de 6 J. Não houve alteração na quantidade de fibroblastos de quelóide nas doses aplicadas após 24 horas da irradiação.